AMD Instinct MI300X 192GB vs NVIDIA H100 SXM5 80GB

The Instinct MI300X is the newer part: CDNA 3, launched in 2023, against the H100's Hopper from 2022. Newer architectures typically add lower-precision formats and better throughput per watt, so check the precision rows your workload actually uses.

Dense throughput for the Instinct MI300X against the H100: FP64 82 vs 34 TFLOPS, FP32 163 vs 67 TFLOPS, FP16 1,307 vs 990 TFLOPS, FP8 2,615 vs 1,979 TFLOPS. Sparse figures, where the vendor publishes them, appear under each dense number in the performance table.

Memory is 192 GB against 80 GB, fed at 5.3 TB/s versus 3.4 TB/s. More memory per GPU means larger models fit before you have to shard across cards, which often matters more than raw TFLOPS for inference.

Power budgets are 750 W for the Instinct MI300X and 700 W for the H100. At FP32 that works out to 0.22 against 0.10 TFLOPS per watt.

For LLM training and inference, weight the FP8 and FP16 rows and memory capacity most heavily. For scientific and HPC workloads, the FP64 row is the one to read.